Global Grand Challenges: Environmental niches of Salmonella Typhi [Bill & Melinda Gates Foundation]

Proposals Due: 10.4 2019. Proposals sought to examine the environmental niches of S. Typhi, including (1) Survival of S. Typhi in the context of the soil and water microbiomes; (2) Survival of S. Typhi within other organisms; and (3) Impact of environmental niches on the development of antibiotic resistance in S. Typhi.

The Challenge is open to both domestic and international organizations, including non-profit organizations, for-profit companies, international organizations, government agencies, and academic institutions.

Grants Range: USD $100,000 per project. Funded projects will have one opportunity to apply for a follow-on award of up to USD $1,000,000.

Interest Areas

  • Studies of S. Typhi in the context of soil and water microbiomes, with clear implications for survival, virulence, or antibiotic resistance.
  • Examining survival of S. Typhi within or in the presence of free-living protozoans
  • Examining the role of the environment (soil, water, residual antibiotics) in the development of AMR in S. Typhi
  • Transcriptome analysis and mutagenesis of S. Typhi to identify genes associated with particular environmental niches.

Ineligible Actions

  • Studies of only other Salmonella enterica serovars, without a focus on S. Typhi
  • Clinical studies of typhoid with no environmental focus
  • Solely lab-based mutagenesis studies of S. Typhi with no data to link findings to environmental samples or typhoid epidemiology